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Is aspirin the safest pain reliever? Aspirin is in a class of drugs known as NSAIDs. It's not an NSAID. "For pain relief, especially in older adults that may have things like arthritis, the safest option for pain relief is acetaminophen," Vardeny says, "because it doesn't have the same risk for stomach effects and bleeding." Is Suboxone a synthetic opioid? Suboxone, like methadone, is a synthetic opioid. This drug is made with 80 percent buprenorphine, a partial opioid agonist, and 20 percent naloxone, a medication used to block the effects of opioids.
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